The re-emergence of vaccine-preventable disease should surprise no-one that’s been following the anti-vaccine movement.
Dealing with anti-vaccinationists is like a game of whack-a-mole, where the moles are the same old tropes that keep popping up, no matter how often they are refuted with facts. Vaccines are a remarkable success of modern medicine: They are health interventions that are both demonstrably effective and remarkably cost-effective. Vaccination has likely prevented more deaths in the past 50 years than any other health intervention. Smallpox was a ruthless killer that took 300 million lives, just in the 20th century alone. Today it’s gone – eliminated forever. And now there are now over two dozen diseases that are vaccine-preventable. They should be an easy sell, and to most people, they are. But the control of vaccine-preventable disease relies in part on herd immunity – sufficient immunization to stop the spread of infection (no vaccine offers 100% protection) and protect those that cannot be immunized. Even a modest number of unvaccinated individuals can lead to reemergence of disease. None of this matters to antivaccinationists, to whom vaccines are bad. Viewing anti-vaccine websites for only five to ten minutes can increase the perception of risk of vaccination, and decrease the perceived risk of omitting vaccines. It also lowers vaccination intentions. By changing perceptions of safety, the willingness to vaccinate decreases. Now imagine that someone you believe to be a health professional openly questioned the efficacy and safety of vaccines – would it reduce your willingness to vaccinate? The evidence says it does. And that’s why the modern practice of naturopathy or “naturopathic medicine” is so concerning. Naturopaths have opposed vaccinations since the invention of naturopathy – starting with smallpox: Continue reading
Does Tamiflu have any meaningful effects on the prevention or treatment of influenza? Considering the drug’s been on the market for almost 15 years, and is widely used, you should expect this question has been answered after 15 flu seasons. Answering this question from a science-based perspective requires three steps: Consider prior probability, be systematic in the approach, and get all the data. It’s the third step that’s been (until now) impossible with Tamiflu: Some data was unpublished. In general, there’s good evidence to show that negative studies are less likely to be published than positive studies. Unless unpublished studies are included, systematic reviews are more likely to miss negative data, which means there’s the risk of bias in favor of an intervention.
The absence of a full data set on Tamiflu (oseltamivir) and the other neuraminidase inhibitor Relenza (zanamivir) became a rallying point for BMJ and the AllTrials campaign, which seeks to enhance the transparency and accessibility of clinical trials data by challenging trial investigators to make all evidence freely available. (Reforming and enhancing access to trial data was one of the most essential changes recommended by Ben Goldacre in his book, Bad Pharma.) In 2009, Tamiflu’s manufacturer, Hoffman-La Roche committed to making the Tamiflu data set available to investigators. Now after four years of back-and-forth between BMJ, investigators, and Roche, the full clinical trials data set has been made freely available. An updated systematic review was published today in BMJ (formerly The British Medical Journal), entitled “Oseltamivir for influenza in adults and children: systematic review of clinical study reports and summary of regulatory comments.” This will be a short post covering the highlights. As the entire study and accompanying data are freely available, I’ll await continued discussion in the comments. Continue reading
Happy 2014 Everyone! It’s been a while since the last weekend reading update. Here’s some links and posts for your reading pleasure. The picture above is from the Toronto ice storm that we’re still recovering from. Continue reading
It’s Thanksgiving! Here’s a quick list of some links of interest. If this is your long weekend, enjoy! Continue reading
Vitamin K is given routinely to newborns to prevent vitamin K deficient bleeding. It’s injected intramuscularly to prevent early and late cases of gastrointestinal and brain bleeding, which can permanently injury or kill. Without Vitamin K, this is estimated to occur about 3 to 17 times per 1000 newborns. However, due to fearmongering misinformation from people like Joe Mercola, some parents are refusing this potentially lifesaving therapy for their newborn. As you might expect, there have been consequences: Continue reading
The title of this post may suggest I’m making a point that’s beyond obvious. But sometimes the obvious needs to be stated, especially when it comes to the anti-vaccine movement. I was appalled after watching this clip from CBS news about Alex Spourdalakis, a 14-year old boy with severe autism who was brutally murdered by his mother and caregiver. The clip involves CBS journalist Sharyl Attkisson who is demonstrably anti-vaccine. So what does a well-known anti-vaccine journalist have to do with the brutal filicide of a 14-year old autistic boy? Continue reading
It’s Labour Day weekend, which is a long weekend for many of you. Here’s some articles of interest: Continue reading
Heroin and Cocaine lozenges will make anyone’s throat feel better.
It’s hard to believe that summer is actually winding down here in North America. Summer vacations are wrapping up and school is starting soon. The header image from today’s post is from i09, Gorgeous Vintage Advertisements for Heroin, Cannabis and Cocaine. Here’s some additional posts worthy of your attention: Continue reading
It’s the peak of summer and much of the Eastern seaboard has been melting under record heat. Here’s some links of interest:
It’s the peak of summer in North America. Posting will become even more sporadic as some well-deserved vacation occurs. Here’s some dockside reading: Continue reading